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Epithalon and Tumor Metastasis in Mice In female C3H/He mice with spontaneous tumors of the reproductive organs (mammary glands and ovaries), Epithalon was studied for its effects on tumor behavior.(9) Study observations: Control mice showed progressive tumor growth and metastasis in 3 of 9 animals Epithalon-treated mice demonstrated reduced tumor cell counts and fewer metastatic lesions The peptide appeared to inhibit metastatic progression and limit tumor cell proliferation These findings led researchers to propose a possible anti-metastatic activity of Epithalon in this specific model