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Spectrometric, biochemical, immunoblot, and immunohistochemical analyses were performed to assess the hepatic redox-active Fe 2+ intensity, metabolic function, anti-oxidative enzyme expression, and the pro-inflammatory cytokine levels

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These findings suggest that optimal NAMPT levels and activity are critical for healthy aging and overall organismal homeostasis, and both upregulation and targeted inhibition may offer potential interventions depending on the specific context and tissue