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The results found no detectable CYS3 expression in the knockout mutants and intermediary levels of CYS3 expression in all 3 complemented strains relative to wild type (Supplementary Fig

When you start with a clinical population like this, the findings are often a bit scary

Several peptides have been developed specifically for NADs delivery based on these unique properties for cell targeting, penetration, endosomal escape, and sub-organelle targeting (Fig