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Nor do they start from the same reserve levels

474 (7351):307-17 Available from: 5

96,97 Furthermore, genetic mutations in NF-B-stimulating immune receptors, such as NOD2, and NF-B target genes, such as IL-12 and IL-23, are associated with human IBD

These improvements occurred alongside a marked reduction in TPO-Ab titres and were hypothesised to result from immunological downregulation following removal of the antigenic stimulus ( Figure 1 )