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Reduction in estrogen levels throughout aging and menopausal periods is suggested to be associated with increased oxidative stress and mitochondrial dysfunction, exacerbated proinflammatory responses, and reduced synaptic plasticity (249, 254, 255)

In contrast, coal-derived CQDs exhibited potent inhibition of SARS-CoV-2 replication in vitro , achieving more than 95% reduction in viral growth at half-maximal inhibitory concentration (IC 50 ) of approximately 5.47 g/mL, with minimal cytotoxicity in normal cell lines, indicating genuine antiviral activity in a human-relevant viral system [123]

These findings emphasize SAs critical role in inflammation-related diseases and pave the way for its therapeutic applications in various disease contexts

PI3K: Phosphatidylinositol 3-kinase-delta