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However, the OS benefit is questioned by some experts because of deaths unrelated to treatment or disease and because 31 % of FCR patients did not complete all six treatment cycles

doi: 10.3389/fcell.2025.1605174 Received 02 April 2025 Accepted 25 August 2025 Published 01 October 2025 Volume 13 - 2025 Edited by Asok K

Moreover, the administration of nobiletin and clonazepam can significantly upregulate the phosphoinositide 3-kinase/protein kinase B (PI3K/Akt) signaling (Yang et al., 2018)