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Weidenfeller, C., Svendsen, C

Opposite roles of selenium-dependent glutathione peroxidase-1 in superoxide generator diquat- and peroxynitrite-induced apoptosis and signaling

These hydroxyl radicals induce lipid peroxidation, protein oxidation, and DNA damage, ultimately contributing to the initiation and progression of atherosclerosis ( Moreover, copper deficiency may also augment mitochondrial oxidative stress by suppressing COX (complex IV) activity, which impairs electron transport chain function and secondarily increases ROS formation (Johnson and Thomas, 1999)