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Diazepam and its metabolites are excreted mainly in the urine, predominantly as their glucuronide conjugates

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In the latter example, Changs group 55,56,57 , crosslinked the polyhemoglobin (polyHb) with antioxidant enzymes SOD and CAT, and carbonic anhydrase (CA)

However, ncRNA alterations remain highly inconsistent across drugs, brain regions, and experimental paradigms, highlighting the need for more causal, cell-type-specific, and temporally resolved studies (Fig