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Description

NCOA4, involved in ferritinophagy, plays a critical role in the selective autophagy of ferritin, contributing to ferroptosis by enhancing ferritin degradation and triggering the Fenton reaction in human bronchial epithelial cells [99]

They include heart failure, vision loss, stroke, kidney disease and other health problems

In contrast, impaired tissue glucose uptake in response to insulin (a phenomenon called insulin resistance) plays a key role in the development of type 2 diabetes (55)