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Figure 1 Autoimmune mechanisms have also been implicated in the pathogenesis of HIVAC through HIV-induced B-cell stimulation leading to autoantibody production directed against the myocardium ( 3 Clinical manifestations and diagnosis 3.1 Signs and symptoms Like other forms of cardiomyopathy, peripheral edema, involving the legs, ankles, feet, or abdomen, frequently results from fluid retention secondary to compromised myocardial function