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In the absence of Wnt ligand, -catenin may be phosphorylated by the -catenin destruction complex composed of Axin, glycogen synthase kinase 3 (GSK3 ), casein kinase 1 (CK1 ), and adenomatous polyposis coli (APC) and subsequently degraded by the E3 ligase -TrCP [246]

In some cases, patients have reported issues such as ruined skin , usually due to excessive application or improper formulation

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