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The observed inactivation rate constant ( k obs ) at each inhibitor concentration was calculated from the negative slopes of the linear regression lines obtained by plotting the natural logarithm of the remaining enzyme activity against preincubation time

VEGF is phosphorylated after binding to VEGFR-3 and this activates p42/p44 MAPK transduction through the Ras-independent pathway and promotes the proliferation of lymphatic endothelial cells (48)

Its ligand effect on NAD + catalysis was determined on mPCs isolated from the BM plasma of MM patients and, for comparative evaluation, on a continuous human myeloma cell line

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