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The impact of fat mass on brain mass reduction is attributed to the correlation between elevated body fat and heightened proinflammatory status, as well as enhanced oxidative stress, as measured by isoprostanes [215]

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Inhibition of NAMPT exacerbates hepatic steatosis induced by HFD via the SIRT1/AMPK/SREBP1 pathway (Shehata et al

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doi: 10.1089/ars.2010.3586 36 ReganEABowlerRPCrapoJD

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