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Description

Accumulating in vitro evidence indicates that nuclear HDAC13 are the most potent lysine delactylases, whereas SIRT13 also exhibit substantial delactylation activity toward both L- and D-lactyl modifications

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25,211,492 In addition to targeting fragile X syndrome, mGluR5 inhibition has been shown to salvage many phenotypes, including learning and memory deficits, social deficits, repetitive behaviours, hyperactivity, and dendritic spine dysmorphogenesis, in 16p11.2 deletion mice, BTBR mice and Shank3- knockout mice

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Noteworthy, mitochondrial FRT has not been detected in DRG neurons, a protein responsible to store free mitochondrial iron and with a very important role in antioxidant activity (Koeppen et al., 2007

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