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In eukaryotic organisms, HMGB1 protein is mainly found in the nucleus, where its function is chaperoning DNA molecules alleviating replication, recombination, transcription, DNA repair, and nucleosome formation stabilization by forming the DNA helical structure and promoting the binding of regulatory complexes to DNA

Research suggests it supports tissue regeneration, modulates inflammatory signaling, and encourages the formation of new blood vessels, making it a compound of interest in experimental models involving wounds, ulcers, and soft tissue recovery

Genome-wide CRISPR-Cas9 screens expose genetic vulnerabilities and mechanisms of temozolomide sensitivity in glioblastoma stem cells

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