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In addition to skin whitening, the treatment will reverse oxidative stress, enhance liver functioning, and immunity

As the research presented in this manuscript is highly relevant to the local communities of the DRC, input from the local physicians, scientists and students who are familiar with konzo have been instrumental to the successful outcome of this study

This also raises the question whether PARP activity in BRCA1/2-deficient tumors produces a similar metabolic phenotype via NAD + depletion and whether the use of a PARP inhibitor (e.g., olaparib) to treat these tumors 10 might restore NAD + levels and counterbalance GAPDH inhibition by other oxidative agents

10.1016/j.neuroscience.2007.08.028 Neuroscience