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For example, reduced EAAT2 activity leads to elevated extracellular glutamate concentrations [309, 310], which trigger excessive calcium influx into both neurons and astrocytes

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and R 8 is H, C 1-4 alkyl, halogen-substituted C 1-4 alkyl

Collectively, these non-canonical glycine signaling modalities remain preliminary and require further replication, mechanistic dissection, and in vivo validation to establish their physiological relevance and translational implications (Bossi et al