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For additional background on these emerging areas of study, see our discussion of amylin protein as a therapeutic target in Alzheimers disease

Transcriptomic studies have characterized the compound as influencing the expression of a large number of genes, published analyses have reported effects on the expression of more than four thousand human genes, across the directional categories studied, with notable enrichment in pathways related to extracellular matrix remodeling, cellular proliferation, antioxidant response, and copper homeostasis

doi:10.1136/heartjnl-2019-315130 Evensen LH, Brkkan SK, Hansen JB

The details and characteristics of each of the individual outcome trials were published in recent reviews [25]