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Moreover, because of the significant morbidity and mortality associated with the disease, a recent study revealed that liver cirrhosis is associated with 2.4% of deaths worldwide [1]

Jung et al., 2018)

(2003, July) Column Packing for Process-Scale Chromatography: Guidelines for Reproducibility

The agency noted that it approved 46 novel drugs and biologics last year, including 43% that were first-in-class, and half that were for rare or orphan diseases