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GSL synthesis inhibitors are also able to regulate osteoclastogenesis by interfering with RANK, c-Src and TRAF6 co-localization in the lipid rafts, ultimately interfering with the signaling cascade that activates the NF-kB pathway and the subsequent transcription of osteoclastogenic genes [134]

For example, S.aureus triggers an inflammatory phenotype of keratinocytes with inflammatory cytokine release, inflammasome activation and AMP production, also causing keratinocyte death [55]

10.1073/pnas.1603907113 168 ScolesD