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Allergens that would normally bounce off intact skin penetrate through the gaps and activate the immune response beneath

However, those with specific autoimmune conditions (particularly psoriasis or rosacea, where LL-37 is naturally overexpressed locally) should consult with their healthcare provider, as adding exogenous LL-37 could potentially exacerbate hyper-immune responses in those highly specific contexts

The short dihexa half life is a pharmacological advantage, not a limitation it allows precise temporal control over receptor activation without accumulation toxicity or prolonged systemic exposure

Effectiveness of low-fat diet on the levels of insulin-like growth factor-1 and insulin-like growth factor binding proteins: a systematic review and meta-analysis of randomized controlled clinical trials