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The beneficial effects of selected NMs on metabolite enhancement have been demonstrated in several studies

GSH and GSSG are found outside cells, but normally at very low concentration100 to 1000 times less than intracellular GSH

Autophagy 16:19491973 Lee H, Zandkarimi F, Zhang Y, Meena JK, Kim J, Zhuang L, Tyagi S, Ma L, Westbrook TF, Steinberg GR, Nakada D, Stockwell BR, Gan B (2020b) Energy-stress-mediated ampk activation inhibits ferroptosis