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Exposure via water would only be significant in cases of ingestion of, or skin contact with, acrolein deliberately applied as a biocide to irrigation water

B12 is extremely delicate and becomes unstable when exposed to light, rendering a large majority of B12 supplements as useless, due to poor manufacturing and packaging processes

It is presently accepted that genetic susceptibility, environmental factors, including nutritional factors and immune disorders contribute to the development of AITD

Nevertheless, the clinical application of these modalities requires additional thorough investigation to establish their efficacy, reliability, and relevance in routine clinical practice