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Additionally, the nuclear export signal (NES) in KEAP1 has been shown to be important for NRF2 regulation, as it was found to facilitate the transport of the NRF2-KEAP1 complex out of the nucleus, which terminates NRF2-mediated antioxidant signaling after stress [16]

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FIGURE 1 Despite the big importance that has been given to plasma protein-binding drugs, the study of RBC partitioning has received much less attention over time

Consistent with these findings, another study reported a positive association between free glutamine levels in human milk and infant length at 4 months of age (65)