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The tumor cells that dwell in the origin sites secrete various cytokines floating or packed in vesicles such as in exosomes via bloodstream to activate the metastasis-prone niches, attracting rare tolerant subclones to distant colonization [147, 148]

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Similarly, transplantation of gut microbes from alcohol-fed mice to healthy controls triggered anxiety behaviors similar to those induced by alcohol withdrawal (222)

3584-C OUTCOMES OF LIVER TRANSPLANTATION IN PATIENTS WITH ACUTE ALCOHOLIC HEPATITIS BASED ON WAITLIST DURATION Omar Alshuwaykh, California Pacific Medical Center, George Cholankeril, Baylor College of Medicine, Donghee Kim, Stanford University Medical Center and Aijaz Ahmed, Stanford University School of Medicine Background: Acute alcoholic hepatitis is associated with significant short-term mortality and liver transplantation can be a lifesaving option for these patients