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After an initial increase, levels of ACTH and cortisol decreased near or below baseline levels at week 16 ( Figure 3B ), in contrast to the increase seen in patients with ACTH-dependent Cushing syndrome treated with mifepristone (28, 29)

Our results support that axon injury and ferroptosis signaling triggers PSR-1 condensation on the axonal membrane to facilitate axonal fusion (Fig

HALLMARK gene set enrichment analysis (GSEA) identified suppression of Estrogen Response genes, E2F targets and other proliferation-associated gene sets as being suppressed by giredestrant, consistent with its anticipated effects as an ER antagonist (Supplementary Fig

doi: 10.1016/j.pmpp.2020.101513 139 SoaresJ