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NRF2 in Alzheimers disease AD is the most common neurodegenerative disease and contributes to 60%70% of the 55 million people diagnosed with dementia worldwide (WHO, 2023)

(iii) the effect of sleep stage on the formation of immunological memory through specific immune-active hormones: indeed, during slow wave sleep-rich early sleep, the profile of immune-active hormones, characterized by minimum concentrations of cortisol, endowed with anti-inflammatory activity, and high levels of GH, prolactin, and aldosterone, which support Th1 cell-mediated immunity, may facilitate the mounting of an effective adaptive immune response to a microbial challenge 54

The determination of Se status throughout experiments and self-medication of patients is very important for clarification of outcomes

TrxRs are also NADPH-consuming flavoproteins that exhibit cytosolic (TrxR1) and mitochondrial (TrxR2) localization in mammals