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In a long-term randomized, double-blind, placebo-controlled study among sufferers of cerebrovascular accidents at high risk of depression, daily supplementation with 2 mg of folic acid, 25 mg of vitamin B6, and 500 g vitamin B 12 significantly lowered the risk of major depressive episodes during a seven-year follow-up period compared to placebo (111)

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Supplements: Vegans and vegetarians may need to consider B12 supplements to meet their requirements

Research around AOD-9604 and MOTS-c includes experimental, investigational, and limited human-interest discussion, but evidence quality, clinical standards, and regulatory context can vary