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LL-37 induces mast cells to release IL-31, a cytokine associated with itch and inflammatory skin diseases

a more recent comparison between shorter IV versus longer oral treatments did not find any significant difference in adverse outcomes when patients were treated within 8 hours of the overdose [78]

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In preclinical models of peripheral neuropathy, researchers observed that ARA-290 administration was associated with changes in small nerve fiber density and inflammatory cytokine profiles