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EXTENDED DISCUSSION Biochemical and structural studies of GPX4 and its inhibitors have been hindered by the lack of an efficient source of wild-type GPX4 protein 5,49,50

Applying the mass analysis of copolymers (MACO) statistical model to the spectra, we show that the MACO/MALDI-TOF mass spectrometry (MS) analysis can be successfully applied to copolymers having a difference between the mass of the comonomers as small as 1 g mol -1 (the styrene and 4-vinylpyridine units are 104.15 and 105.15 g/mol, respectively), which results in overlapping isotopic patterns