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Transepithelial electrical resistance (TEER) measurements assess the integrity of tight junctions higher TEER values show better barrier function

For example, chitosan-modified taxifolin liposomes, via the specific binding between the cationic properties of chitosan and anionic sites on the surface of renal endothelial cells, not only enhance drug absorption efficiency and bioavailability but also accurately target renal injury sites, reduce total cholesterol and triglyceride levels in diabetic mice, alleviate damage to the glomerular filtration barrier caused by lipid metabolism disorders, and thereby protect renal function [201]