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In the case of anti-TNF, the German BiKeR registry shows that 9 years of etanercept use in pediatric and adolescent rheumatoid arthritis patients did not observe new tumor or autoimmune risks during follow-up

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Sleep-inducing effects of TNF-alpha were also first described in rabbits

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147 In addition, BGP-15 exerts protective effects against diabetic complications, including retinopathy and cardiomyopathy, supporting its potential utility in T2DM and related metabolic disorders

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J Biomed Res 2013;27:254-71

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