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Plant Methods 13, 64

In a murine model of non-alcoholic fatty liver disease, downregulation of miR-130b-5p, which targets IGFBP-2, prevented lipid accumulation and insulin resistance by increasing IGFBP-2 and AKT activation [80]

Studies support a bi-directionality of causation between inflammation (vascular or otherwise) and CHIP, and as CH exacerbates insulin resistance in preclinical models (278, 279), the hypothesis that critical illnesses can drive CHIP must be taken seriously (280)

In a study of 72 patients with OSF and 30 healthy individuals, the researchers identified OSF development associated with enrichment of Th17 cell and IL-17 infiltration occurred in the tissues and PBMCs of patients with OSF