glutathion peroxydase élevé Glutathione peroxidase Mechanism of glucocorticoid-induced oxidative stress

873 The expression of ACSL4 and 4-HNE increase in the cartilage of OA patients and OA mice, while metformin increases p-AMPK and p-ACC levels in IL-1-treated chondrocytes, reverses ACSL4 and 4-HNE positive chondrocytes and OA lesions, and improves the ferroptosis sensitivity of chondrocytes through the AMPK/ACC pathway

Loss of membrane integrity during ferroptosis is caused by lipid peroxidation mediated by oxidoreductases, which depend on iron, ROS, and polyunsaturated-fatty-acid-containing phospholipids (PUFA-PLs)

Fr die Eumetabol-Therapie sind weder allgemeine Nebenwirkungen noch Wechselwirkungen oder berdosierungen bekannt

doi: 10.1093/toxsci/51.2.161