lysosomal glutathione cystine: an unexpected alarm bell for cysteine scarcity: Trends in Cell Biology Frontiers | Glutathione: A Samsonian

Frontiers Glutathione: A Samsonian life sustaining small molecule that protects against oxidative stress, ageing and damaging inflammation Ferroptosis regulation in lysosome Lysosomal iron and cathepsin B contribute to ferroptotic cell death. Lysosomal cyst(e)ine can be mobilized to maintain glutathione synthesis and glutathione peroxidase 4 activity, thereby limiting lipid peroxidation. Cell type resolved protein atlas of brain lysosomes identifies SLC45A1 associated disease as a lysosomal disorder: Cell Science Note: Lysosome DOJINDO LABORATORIES

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