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Acknowledgements This study was partially supported by grants of the Russian Foundation for Basic Research (11-04-00843, 12-04-31528, 13-04-40083-), and the Molecular and Cell Biology Program of the Russian Academy of Sciences, and the Federal Program for Support of Scientific Schools of the Russian Ministry of Science and Education

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Cardiolipin can be oxidized by ROS or by the cardiolipincytochrome c complex ( c from cardiolipin might also be triggered by increased cytosolic calcium, which weakens the electrostatic interaction between cytochrome c and cardiolipin and further generates ROS via MPT