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Mol Cancer 24 , 288 (2025)

Sarcoplasmic reticulum Ca2+ uptake and leak properties, and SERCA isoform expression, in type I and type II fibres of human skeletal muscle

The metabolism of PAHs, such as benzo[a]pyrene, predominantly relies on GSTs, which conjugate the highly carcinogenic epoxides with glutathione, producing water-soluble metabolites that are excreted via bile or urine, thereby reducing accumulation in target organs and the risk of DNA damage (Alexandrie et al., 2000