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As illustrated in Figure 6 , Uniform Manifold Approximation and Projection (UMAP) clustering enables the clear identification of the complex renal cellular landscape, encompassing core cellular populations including endothelial cells (EC), fibroblasts (FIB), vascular smooth muscle cells/pericytes (VSM/P), immune cells (IMM), podocytes (POD), neutrophils (NEU), proximal tubule cells (PT), parietal epithelial cells (PEC), interstitial cells (IC), papillary epithelial cells (PapE), principal cells of collecting ducts (PC), connecting tubule cells (CNT), distal tubule cells (DCT), descending thin limbs (DTL), and thick ascending limbs of Henles loop (ATL and TAL) ( Figure 6A )

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Some cancer cells are very dependent on Mcl-1, which is the last line of defense keeping the cell from dying