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Besides these differences, key amino acid residues of catalytic and flexible loops constituting the bifunnel active site existing between the adjacent monomers, and residues interacting with metal and ammonium ions, water molecules, ATP and glutamate are conserved in Plasmodia GS 19,20 (Fig

10.1002/ar.22677 161 TeradaY.OguraJ.TsujimotoT.KuwayamaK.KoizumiT.SasakiS.et al (2014)

JP: Conceptualization, Funding acquisition, Writing original draft, Writing review & editing

11.2 Designer probiotics and synthetic biology innovations While the application of probiotics to address health issues has a long history, contemporary breakthroughs in culturomicsnotably through gnotobiotic animal modelshave catalyzed the evolution of a novel scientific frontier dedicated to engineering host-specific probiotic therapeutics (537)