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Similar neuroprotective effects have been observed in mouse models of rotenone-induced PD as well, through the inhibition of -synuclein phosphorylation and aggregation, protection of mitochondrial function, inhibition of neuroinflammation, modulation of autophagy, attenuation of oxidative stress and restoration of ER balance (Wang D

General observations: High doses may cause mild digestive upset in some people Sensitive individuals occasionally report headaches or restlessness People with kidney conditions or rare genetic disorders should be cautious If youre pregnant, elderly, managing chronic illness, or already taking medications, its usually sensible to discuss supplementation with a qualified professional

Glu, however, as a novel signaling molecule in plants, the following open questions look forward to being uncovered in the future: 1) the detailed mechanisms of Glu-triggered abiotic and biotic tolerance, especially heat tolerance, will be illuminated at physiological, biochemical, molecular, and even omics levels