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Treadwell T, Kleinman HK, Crockford D, Hardy MA, Guarnera GT, Goldstein AL

It is now generally accepted that the photolysis of alkyl cobalamins results in formation of cob(II)alamin and alkyl radical pairs, similar to the intermediates from (AdoCbl)-dependent enzymatic catalysis

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May be a marker of underlying disease (e.g., liver disease, malignancy, MDS/CML)