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An optimal index is consistently linked to better brain function and a lower risk of age-related cognitive decline

By mapping the cascade from zinc imbalance to molecular dysfunction, organelle stress and disease expression, the framework provides an early overview that anchors the detailed sections that follow and highlights mechanistic points of intervention with potential relevance for future therapeutic modulation 18,19,20,21

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Variations in substrate selectivity among DPP-4 inhibitors may further influence cardiovascular outcomes, while patient population heterogeneitythrough altered pharmacokinetics or pharmacodynamicscould amplify these disparities