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Numerous studies suggest that neurotoxins may interact with -synuclein or other proteins connected to Parkinsons disease to influence the etiology of the disease (Klein and Westenberger, 2012)

An imbalance of the gut microbiota can lead to immune activation and inflammation, particularly through an increase in pro-inflammatory lipopolysaccharides (LPS), which results in increased production of inflammatory cytokines, such as TNF-, IL-1, and IL-6 (218)

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Hydroxysafflor yellow A can improve depressive behavior by inhibiting hippocampal inflammation and oxidative stress through regulating HPA axis