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p = 0.0006), while again showing no significant difference between co-administered groups (Fig

To facilitate targeted protein degradation, molecular glues such as immunomodulatory imide drugs (IMiD, e.g., thalidomide, lenalidomide, pomalidomide) generate a novel interaction between a substrate (e.g., IKZF 1/3) [317, 318] and cereblon, a substrate receptor for CRL4 [319, 320]