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In the anti-oxidative stress regulatory network, Nrf2 is the upstream pathway, which is involved in regulating the expression of various antioxidant enzymes such as CAT, SOD, NQO-1, HO-1, etc., and decreasing the intracellular reactive oxygen species and malondialdehyde content

there were no overall differences in small blood vessel problems such as those found in eyes, nerves, and kidneys between participants from the DPP Lifestyle Change Program and participants who continued to take metformin or took a placebo