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On the other hand, chelerythrine has other effects, for example, it can affect multiple ion channels in cardiac tissue in a pkc-independent manner (Son et al., 2011), but also anti-inflammatory effects via a pkc mechanism, with pkc acting as an upstream regulator of the pro-inflammatory PKC/NF-kappaB pathway (Zeng et al., 2015)
This vicious cycle leads to DAneuron loss, particularly in the SN, and is further exacerbated by impaired iron export mechanisms (Figure 3)
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