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Etiological factors in CM theory include gallstone obstruction, dietary irregularities (e.g., excessive greasy food), emotional disturbances ( Gan Yu ), trauma, and invasion of exogenous pathogens ( Liu Yin ) (Wu, 2002), all of which may exacerbate the progression of AP

ROS, Reactive oxygen species

A., Xiaowen H., Wang M

While this packaging protects the DNA from some forms of damage, it also limits the sperm cells ability to repair oxidative damage, such as DNA fragmentation caused by ROS