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1,3 Disulfides are thermodynamically stable at physiological pH and are designed to release the conjugated payload drug upon internalization into the tumor cells, where the cytosol provides a much stronger reducing environment compared to the extracellular environment (blood circulation)

In adult brains, GPX4 is detected in the neurons of the cerebral cortex, hippocampus, and cerebellum

Declaration of Interests Statement SaT is the inventor of Plasmax TM cell culture medium

24 Caution must be taken with loperamide and most antinausea medications, including ondansetron and promethazine, as they can cause QTc prolongation or exacerbate the QTc prolongation from other medications used for OWS