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While chronic infections with HBV and HCV, heavy alcohol consumption, and diabetes are well-established primary risk factors for HCC, there is compelling and growing evidence that prolonged and active cigarette smoking is an independent and significant risk factor for its development [98, 99]

This reduction was associated with decreased IL-17A levels and attenuated connectivity between inflammatory factors

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Wallock L, Tamura T, Ames B, Johnston K, Gretz D, Improvements in folate indices in blood and seminal plasma following vitamin supplementation in smokers and nonsmokers [abstract]., FASEB J, p