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Participants received no financial compensation for taking part in this study

In this sense celecoxib showed to be a safe and a highly effective therapeutical option in resistant bipolar depression, reducing anxiety and accelerating treatment response [335], in a similar way to aspirin [336]

PMID: 35 HanKLiJYinSHuHZhaoC

When taken orally, metformin is concentrated in the intestine at levels up to 300 times greater than in the blood, significantly influencing the composition and metabolism of the gut microbiota [16]